Regular Exercise Can Help You Overcome the ‘Obesity Gene’

Physical activity appears to lower effects of key DNA linked to weight gain, study finds

Even if obesity is “in your genes,” regular exercise can help keep extra pounds at bay, a new study suggests.

Researchers found that when people carried a particular gene variant that raises obesity risk, regular exercise seemed to reduce the effects of their DNA — by about one-third.

The gene in question is known as FTO. Studies show that people with a particular variant of the gene have a heightened risk of obesity.

But the gene’s effects are not huge, or written in stone. Research has found that people who carry two copies of the FTO variant (one inherited from each parent) weigh about 6.5 pounds more than non-carriers, on average.

The new findings underscore one way to counter the gene’s impact: Exercise.

“There are genes that appear to directly impact weight, but the effects are small,” said lead researcher Mariaelisa Graff, of the University of North Carolina at Chapel Hill. “You still have a lot of choice over your behavior.”

The study results are not exactly surprising, according to Dr. Timothy Church, an obesity researcher who was not involved in the work.

“This shows, once again, that genes are not your destiny,” said Church. He is a professor of preventative medicine at Louisiana State University’s Pennington Biomedical Research Center.

Church said regular exercise is particularly key in preventing excess weight gain in the first place — and in keeping the pounds off after someone loses weight.

Exercise is less effective in helping obese people shed weight, Church said. Diet changes are the critical step there.

But the bottom line is that exercise matters, regardless of your genes, according to Dr. Chip Lavie, of the John Ochsner Heart and Vascular Institute, in New Orleans.

Lavie, who was not involved in the study, pointed to findings from his own research.

“[We] have published data that suggests the main cause of increasing obesity over the past five decades is the dramatic decline in physical activity,” he said.

Gym memberships aside, Americans these days are less active at work, at home (through housework) and during leisure time, according to Lavie.

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SOURCE: HealthDay News
Amy Norton